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For Miss Simpson. ✍

- Being better now more aquainted with the Circumstances of the
case I can judge better of it; & tho I am much of the same
opinion with respect to the nature of it as before, I think more
Slightly of it, and have better hopes of her recovery: and es¬
specially as no degree of hectic is yet formed. - I am also
of the same opinion as before with respect to the measures to be
taken for M. S..s recovery, but shall give a four more

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particular discretions with regard to the conduct of them. --

I have caused prepare a parcell of pills of the Cicuta of
such quantity, as I can depend upon, as far as we can
depend upon any of it before trial. Of these pills Miss S.
is to take one every night and Morning - The morning dose is
to be taken at least half an hour before breakfast.

The Evening dose before going to bed. It is the morning
dose that is to be particularly observed & it should give
some feeling of sickness at Stomach, lightness across the
breast, some degree of giddiness or of tremor. If the first
dose in the morning has any such effects, it is enough, but I do
not expect any effects from the smallness of the dose, that a
small single pill contains; and therefore I would have her
increase the dose by one pill every day: so that she takes
two pills the 2d day, thrice the third, & so on till she
takes five for a dose. If five pills have no effect as
increasing the number may be troublesome, I would have
a new mass of pills to be formed, each Pill containing
four grains of the powder & for this purpose I have sent a
Parcel of this powder in a Phial. - If it shall be found
necessary to go on increasing the dose Miss S. may proceed
till she take 20 grains taken in the morning has none of the
and if then 20 grains taken in the morning has none of the
effects mentioned above, she is to suspect that the powder
is not of so good a quality as it ought to be & must try
another Parcel. For there is hardly any of it to be trusted
without a trial. If it shall happen as I hope it

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may that at a certain dose, some of the effects above mentioned
shall be observed, Miss S. is to continue to take the medicine
without increasing the dose for two weeks together, or as long as it
continues to have in any degree any sensible effects. If in the
course of two or three weeks, it ceases to have any sensible
effects, the dose may then be increased to five grains more &
then continued as before. I have only further to observe at
regard to this medicine that if the larger doses of it taken
in pans (↑Pills↑) shall be found to be troublesome, the dose may be
made into a bolus with a little Syrup, and swallowed in a
wafer. With respect to the Mercurial Medicine I dare say
that any Gentleman of tolerable Experience, especially Mr
Lambert will be able to conduct it very properly. but to
satisfy the Ladie's friends I shall here give particular
directions. Let the quicksilver be long and diligently rubbed
with honey till it is quite extinguished, & then with
fine crumb of stale bread, let a mass be formed to
that there may be half a grain of quicksilver, in
every three or four grains of the mass & let it be formed
into Pills each containing half a grain of the quicksilver

Of these M. S. is to take one every night & morning along
with the dose of Cicuta. It is probable that she may take these
Pills for a week or more without feeling any effects from
them but this operation is to be watched & they are to
be managed accordingly. If they move her belly & that
not above once a day (↑very moderately↑) not above once a day, they may be
continued at the dose mentioned for some time, but if they

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should give a loose stool or more than one, the dose
must be brought to half again at bed time only. & if even
the single dose should move her belly, she must have
ten or fifteen drops of Tinctura Thebaica with her Evening
dose, & if this given every second or third night does not
prevent purging the Mercurial Medicine must be
given up Altogether. But on the other hand it is possible
that the Medicine may not operate by stool, but of in the
course of seven or eight weeks (↑days↑) may threaten to go to her
mouth. If this should happen that she feels any unusual
taste in her mouth, particularly a Copper taste, or that
anyone can perceive any foetor in her breath it will
be then proper to reduce the dose to one half grain at
bed time & even to give it only every second night, or
perhaps for two or three days to intermit it altogether.
according as the Symptoms mentioned shall direct. For
care must be taken that the medicine do not operate
further in the mouth that to taint the breath or to give
Copper taste & the slightest inclination to spit. If it can
be managed in this way for two or three weeks or a
little more, it is likely to be of service to her ailments,
but if it cannot be kept within these bounds it must be given
up altogether. There is some hazard of Miss S.s becoming
hectic & if she should appear to be more than usually heated
by the use of the mercury & especially any night Sweatings
should come on, the Mercury must be laid aside altogether.

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These are the measures I can propose in this difficult case
and if any thing in the circumstances of it, which I can be best
informed of by Mr Lambert cast up I shall be ready to contribute
what further is in my power. ----

The Above for Mr Lambert. the following for MIss Simpson herself.

During the course of medicines she is now to enter upon it will be
particularly necessary for her to guard against cold. For the first six or seven
days that she takes the mercurial pills she may go abroad in a Carriage
for two or three days hours of any forenoon when the weather is tolerably
mild & dry; but she must keep at home for the mornings & Evenings. Then after
taking the Pills for seven or eight days if this show a tendency to go to
her Bowels of that is moderate she may still have some air & Excercise.
but if the tendency appear to be to the mouth, upon the slightest appearance of
that she must keep at home altogether, & even go very little from one
apartment to another: or if in spite of the management I have proposed
the tendency to the mouth should be considerable she must in that case
keep close to her own chamber, & must not quit it till all the symp¬
toms of her mouth have been gone for some days. -- Then Miss S.
begins to use these medicines she may till they have some
sensible effect continue her ordinary diet; but when they begin to
operate she must have her diet ordered in a particular manner.

If the medicine shows a tendency to her bowels she must avoid
all fruit & garden things & all kind of Malt Liquor: but she may
still continue to take a little animal food at dinner. On the other
hand if the medicine shows a tendency to go to her mouth she should
then lay aside all animal food & take to a diet of Milk & grain.

In every situation, a great deal of asses milk will be proper
unless in the particular case that the Asses Milk shows a tendency
to purge her. I should have said above that when she lays aside
animal food she should at the same time leave off taking wine. ---