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Your great medical knowledge which I have
heard [r?]ightly extolled, and my being disquited with an uncom¬
mon disorder, which is very detrimental to my health, induces
me to ask your advice in the curing of it –– the disorder proceeds
from a runing from my privacies in the night when asleep, which
has greatly hurt my animal & intelectual powers, my memory being
extremely hurt, and my spirits much dull'd by it –– it at times, (when
the runing is very frequent) renders me in a manner incapable for any
Business, by greatly weakining & dispiriting me. –– The cause of the
runing is occasioned by a weakness of the seminal vessels, they {illeg} being
able to retain little or non of the semin, which collects in my body
it always runing from me when there is a small quantity collected,
twice thrice or four times a week. –– I apply'd to one of our
principal Surgeons here, whose prescriptions you have below, and
have been advised to the salt water bathing (having tried the
fresh) which sentence putting in Execution, but would wish
to know wither or not you think it will have any good effects

Mr Lyall has used the different Preperations of
the Cortex –– The aluminous medecines, and
the various preparations of Steel have been
continued for some length of time –– The cold
Bath was conjoined with all these without much
effect –– In very cold weather the evacuation
seems to be less in quantity, and not so frequent
The Bals. Copaib. & Elixir Vitrioli were also
taken in considerable doses ––––

The discharge see[ms] [to] be seminal, the
effects mentioned by Mr Ly[al]l are not to me
visible, he appears tolerably plump, Eats
well and seems active –– I doubt not he
is dull & low spirited at times, but suppose his
weakness is more fanciful than real, I thought
necessary to hint this, as his account is rather gloomy ––

Please Direct, William Lyall at Hardie Miller & Co
Glasgow

Doctor William Cullen,
Professor of Medicine
Edinburgh