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I wrote You on Saturday last of
a second Report of the state of Mr. Handasydes Health
since which we have waited with much anxiety for Your
Answer, and as 7 days are now Elapsed we fear by some
mischance the Letter has never Come to Hand.

He has steadily Pursued the Course laid down by You of
Sweating and taking the Diuretick Infusion, but without
any Visible good Effect - The Swelling is very much Increasd.
in the Body and he grows Rapidly Weaker, The diuretick
infusion not having Produced its desired Effects, he became
Tired & Nauseated it so much that he left off taking it as
this Day Week, but he has Continued sweating Every third
day, the day before Yesterday for the first Time he took
the Bolus without having the usual Effect, no sweat Could
be Procured throughout the Day, tho Every Possible means
were used, and when I saw him Yesterday - the Extremities
were much Colder than Usual - and the Pulse Lower, his Purging

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still Continues, but the Pain of his Bowells has been Easier
Ever since he was at Edinburgh. You will very readily Judge
by this report in how Indifferent a state he is - He is perfectly
resigned, and does not flatter himself with any hope of Living
Yet at the same Time - If you Could think of any thing farther
that might be of service to him, would very willing by try it
one Circumstance has Escaped me viz. - within these 4 or 5 days
he has had long & severe Fits of the Hiccough, which
fatigue him Extremely, he is not willing to take any thing
till he hears from You Even for that; If my former letter
has not miscarried, it is likely I may have the Satisfaction
to receive One from You this day or to morrow, but if it
has miscarried I beg the Favour of Your Answer by
first opportunity and In the mean time remain
with Mrs. C --- {illeg} respect

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Dr. Cullen
Edinburgh